What are Rare Cannabinoids?

Rare Cannabinoids

Over the last few years, CBD has become a household name. From CBD tinctures to CBD gummies, and bath bombs to body balms, people are utilizing the natural compound. In fact, one in seven Americans used products containing CBD in 2019, according to a Gallup survey. That number has since increased with some reporting up to one-third of Americans using CBD in 2021.

CBD (cannabidiol) is a non-psychoactive compound found in cannabis and hemp plants. THC (delta-9-tetrahydrocannabinol) on the other hand, is a psychoactive compound – in other words, the part of the plant that gets you high. THC and CBD both work via a system called the human endocannabinoid (EC) system. This system is a unique communications system that affects many important functions of both the brain and the body. However, these are far from the only two compounds found in cannabis and hemp.

In addition to CBD and THC, scientists believe that there are dozens or even hundreds other cannabinoids. These other compounds are called rare – or minor – cannabinoids and researchers say each offers different health and wellness benefits.

Rare cannabinoids are rare because they occur in much smaller quantities than CBD and THC. A rare cannabinoid will make up just 0.01% to 10% of the total mass of the plant. Due to their scarcity, it was extremely difficult to isolate them until very recently.

Fortunately, over the last couple years, advances in genetics and extraction processes have made it possible to separate out some of these rare cannabinoids, namely CBN, CBG, CBC, THCV, CBDV, CBDA, and Delta-8-THC.

Due to the prohibition of cannabis for so many years, research into the potential benefits of these rare cannabinoids is only in its infancy, but initial findings are promising. Some, such as CBDV (cannabidivarin), are already in Phase 2 human trials.

How the endocannabinoid system works

The endocannabinoid system consists of at least two cannabinoid receptors, CB1 (located mostly in the brain and nervous system) and CB2 (found throughout the body), and two key endocannabinoids, anandamide and 2-arachidonylglycerol (2-AG), as well as enzymes. Different cannabinoids have different effects depending on which receptors they bind to. This understanding is what underpins all of cannabis medicine.

Synthetic cannabinoid medicines, including Marinol, Nabilone, and Rimonabant have also been manufactured to bind to specific receptors for specific effects. While they have proven effective, natural cannabinoids, especially when taken in combination with each other to provide the “entourage effect,” are being looked at more closely now that hemp regulations have eased.

Some natural cannabinoids have also been found to provide similar benefits to synthetic cannabinoid pharmaceuticals with less risk of negative side effects. For example, the anti-obesity drug Rimonabant was effective for weight loss but was pulled from the market as it caused major depression in some patients. The rare cannabinoid THCV (tetrahydrocannabivarin) functions in the same way as Rimonabant. It blocks the CB1 receptor and decreases appetite. However, THCV has not been found to produce negative side effects. (You can see the scientific study describing the differences between Rimonabant and THCV on the regulation of reward and aversion in the brain here.)

Potential benefits of each cannabinoid

Each cannabinoid is believed to offer unique mental and physical benefits, based on anecdotal evidence, preclinical research on laboratory animals, and, in some cases, clinical trials on adults and children with specific diseases. Below is a list of rare cannabinoids and their main purported benefits. For more information, please see the linked articles mentioned below as well as our individual product pages and blogs.

CBDV (cannabidivarin) is being studied in children and adolescents with autism spectrum disorder and in adults with seizures. CBDV may also reduce inflammation and nausea and is being researched for muscular dystrophy and other disorders. Learn more and buy CBDV.

THCV (tetrahydrocannabivarin) increases energy and suppresses hunger. THCV also shows promise for type 2 diabetes, anxiety and panic attacks, and nicotine addiction. Learn more and shop for THCV.

CBN (cannabinol) may promote relaxation and restful sleep. CBN is believed to be “more strongly sedative than other known cannabinoids,” especially when it is taken along with THC and/or terpenes that encourage sleep, such as linalool and myrcene. Learn more and buy CBN.

Delta-8-THC (delta-8-tetrahydrocannabinol) is the hemp-derived cousin of “regular” Delta-9-THC, which comes from cannabis. It has been found to relieve pain, inflammation, and nausea. Delta-8-THC is believed to be about half to two-thirds as intoxicating as Delta-9-THC but has less risk of inducing anxiety or paranoia. Learn more and buy Delta-8-THC.

CBC (cannabichromene) has been found to raise levels of the brain’s “bliss” molecule anandamide and is said to be the best non-psychoactive cannabinoid for enhancing one’s mood. Learn more and shop for CBC oil.

CBDA (cannabidiolic acid) has been found to reduce nausea and may fight inflammation in a similar fashion to nonsteroidal anti-inflammatory drugs (NSAIDS). Learn more and buy CBDA.

CBG (cannabigerol) may reduce pain and inflammation and is being researched for use against many ailments, disorders and diseases including multiple sclerosis, Parkinson’s disease, and cancer. Learn more and shop for CBG.

How to take rare cannabinoids

We believe that cannabinoids work best when taken together for the “entourage effect,” whereby the group effect is greater than the sum of their individual parts. We therefore recommend using a full or broad spectrum CBD oil as a base oil and then enhancing it with specific rare cannabinoids tailored to one’s needs. We sell a full spectrum Hawaiian CBD extracted from hemp grown on Maui for this purpose. We also offer a 3000mg CBD. This is a single extract of CBD designed to boost the CBD levels of one’s cannabinoid regime. (CBD promotes stress resilience, calm and reduces inflammation from daily activities and exercise.)

In addition to cannabinoids, hemp and cannabis produce terpenes. These oils also have specific effects in addition to unique aromas. Combining terpenes with cannabinoids can also enhance overall effects. The two terpene-only tinctures we offer are:

Relax Terpenes: This is a blend of myrcene, pinene, carene, limonene, and linalool created to promote rest, relaxation, and sleep.

Relief Terpenes: This is a combination of pinene, limonene, linalool, caryophyllene intended to reduce pain, inflammation, and stress.

Due to FDA guidelines, Rare Cannabinoid Company cannot make claims regarding all of the potential medicinal benefits of these compounds. We encourage our customers to talk to a licensed physician trained in cannabis and do extensive online research to find out how specific cannabinoids may help with their specific ailments or overall wellness. You can also find a Cannabinoid Health Advisor here. These clinics have worked with our products and are knowledgeable about cannabis, hemp, specific cannabinoids, terpenes, blends and associated medical research. Many offer tele-appointments if you can’t visit the clinic directly.

Our goal is to provide you with the tools to control your cannabinoid intake. With our single extracts and enhanced CBD hemp extract blends, you can add exactly as much CBDV, CBDA, CBN, GBG, CBC, Delta-8-THC, THCV or CBD as you like to your daily wellness regime. Our products put you in control and you can even change up your mix depending on your mood and daily physical requirements.

You can see our third-party lab reports for every batch of every product here. Therefore, you know that what our products say on the bottle is what’s inside.